Atherobesity - DFG KFO 152 "Fett und Gefäß"

Subproject 2: Chronic inflammatory activation in the fatty tissue in obesity: an atherogenic factor?

Principal Investigators:

 

Dr. med. Axel Linke Prof. Dr. med. Matthias Blüher
Heart Center Leipzig GmbH Endocrinology and Nephrology Clinic
Universität Leipzig Universität Leipzig
Strümpellstraße 39 Liebigstraße 20
04289 Leipzig 04103 Leipzig
Phone: +49 341 8651671 Phone: +49 341 97 13829
Fax: +49 341 8651461 Fax: +49 341 97 13389
linkea@medizin.uni-leipzig.de matthias.blueher@medizin.uni-leipzig.de

 

Summary of the Subproject:

A chronic inflammatory activation in peripheral and perivascular fatty tissue could be the causal connection between obesity and an increased risk of atherosclerosis. This hypothesis will be analyzed in a combined clinical and molecular study. Thereby it shall be evaluated interventionally, whether molecular alterations in peripheral and perivascular fat tissue could be corrected only through physical training or in combination with a glitazone or metformin therapy in obese patients, whether with these interventions the altered pattern of adipocytocines could be influenced and whether this results in an improvement of endothelial function. For this purpose obese patients with impaired glucose tolerance and coronary artery disease are included in a study with 4 treatment arms. (group 1: training (n=30), group 2: training and glitazone therapy (n=30), group 3: training and metformin therapy (n=30), group 4: conventional therapy).
At the beginning of the study, after 4 and after 24 weeks subcutaneous biopsies of the fat tissue and extensive clinical examinations will be performed. The fat tissue is going to be analyzed with regard to morphological changes, adipocyte gene and protein expression and patterns of secretion. The clinical characterisation of the patients cover: coronary angiography for documentation of coronary artery disease, spiroergometry, euglycemic-hyperinsulinemic clamps, measurement endothelial function, body fat measurement with DEXA-Scan and other methods.

The subproject is not supported financially by the German Research Foundation during the 2nd funding period.

Publications:

  1. Beck EB, Erbs S, Möbius-Winkle S, Adams V, Woitek FJ, Walther T, Hambrecht R, Mohr FW, Stumvoll M, Blüher M, Schuler G, Linke A. Exercise training restores the endothelial response to vascular growth factors in patients with stable coronary artery disease. Eur J Cardiovasc Prev Rehabil. 2011 Mar 22;Epub ahead of print.
  2. Linke A, Sonnabend M, Fasshauer M, Höllriegel R, Schuler G, Niebauer J, Stumvoll M, Blüher M. Effects of extended-release niacin on lipid profile and adipocyte biology in patients with impaired glucose tolerance. Atherosclerosis. 2009;205:207-13.
  3. Oberbach A, Lehmann S, Kirsch K, Krist J, Sonnabend M, Linke A, Tönjes A, Stumvoll M, Blüher M, Kovacs P. Long-term exercise training decreases interleukin-6 (IL-6) serum levels in subjects with impaired glucose tolerance: effect of the -174G/C variant in IL-6 gene. Eur J Endocrinol. 2008;159:129-36.
  4. Fritzsche K, Blüher M, Schering S, Buchwalow IB, Kern M, Linke A, Oberbach A, Adams V, Punkt K. Metabolic profile and nitric oxide synthase expression of skeletal muscle fibers are altered in patients with type 1 diabetes. Exp Clin Endocrinol Diabetes. 2008;116:606-13.
  5. Erbs S, Höllriegel R, Linke A, Beck EB, Adams V, Gielen S, Möbius-Winkler S, Sandri M, Kränkel N, Hambrecht R, Schuler G. Exercise training in patients with advanced chronic heart failure (NYHA IIIb) promotes restoration of peripheral vasomotor function, induction of endogenous regeneration, and improvement of left ventricular function. Circ Heart Fail. 2010;3:486-94.
Imprint | contact | ©2014 Author: Prof. Dr. M. Blüher